Thalamic Shape Abnormalities in Antipsychotic Naïve Schizophrenia

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Neurobiology of Disease Thalamic Shape Abnormalities in Individuals with Schizophrenia and Their Nonpsychotic Siblings

Deficits in the volume of the thalamus have been observed in both individuals with schizophrenia and their nonpsychotic relatives. However, no studies to date have examined the underlying pattern of thalamic shape change in relatives of individuals with schizophrenia. This study examined the volume and shape of the thalamus in schizophrenia subjects, their siblings, and healthy control individu...

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Thalamic shape abnormalities in individuals with schizophrenia and their nonpsychotic siblings.

Deficits in the volume of the thalamus have been observed in both individuals with schizophrenia and their nonpsychotic relatives. However, no studies to date have examined the underlying pattern of thalamic shape change in relatives of individuals with schizophrenia. This study examined the volume and shape of the thalamus in schizophrenia subjects, their siblings, and healthy control individu...

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Abnormalities in glucose regulation during antipsychotic treatment of schizophrenia.

BACKGROUND Hyperglycemia and type 2 diabetes mellitus are more common in schizophrenia than in the general population. Glucoregulatory abnormalities have also been associated with the use of antipsychotic medications themselves. While antipsychotics may increase adiposity, which can decrease insulin sensitivity, disease- and medication-related differences in glucose regulation might also occur ...

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Improvement of brain reward abnormalities by antipsychotic monotherapy in schizophrenia.

CONTEXT Schizophrenic symptoms are linked to a dysfunction of dopamine neurotransmission and the brain reward system. However, it remains unclear whether antipsychotic treatment, which blocks dopamine transmission, improves, alters, or even worsens the reward-related abnormalities. OBJECTIVE To investigate changes in reward-related brain activations in schizophrenia before and after antipsychot...

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Abnormalities of thalamic activation and cognition in schizophrenia.

OBJECTIVE Functional and structural magnetic resonance imaging (MRI) was used to investigate relationships among structure, functional activation, and cognitive deficits related to the thalamus in individuals with schizophrenia and healthy comparison subjects. METHOD Thirty-six schizophrenia subjects and 28 healthy comparison subjects matched by age, gender, race, and parental socioeconomic s...

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ژورنال

عنوان ژورنال: Indian Journal of Psychological Medicine

سال: 2013

ISSN: 0253-7176,0975-1564

DOI: 10.4103/0253-7176.112198